Anti-Aging IV Therapy in Myeongdong Seoul

Intravenous Glutathione for Skin Brightening and Antioxidant Defense

Glutathione (GSH) is the body’s primary endogenous antioxidant, present in every human cell at millimolar concentrations. As the master regulator of intracellular redox balance, glutathione neutralizes reactive oxygen species (ROS), regenerates other antioxidants including vitamins C and E, and directly inhibits tyrosinase — the rate-limiting enzyme in melanin biosynthesis. Intravenous glutathione administration achieves plasma concentrations 10-20 times higher than oral supplementation, because oral glutathione undergoes extensive first-pass hepatic metabolism with only 10-20% surviving to systemic circulation. Anti-aging IV therapy at RE:BERRY Myeongdong exploits this pharmacokinetic advantage to deliver therapeutic glutathione doses that measurably reduce oxidative stress markers and melanin index within 4-6 sessions.

Watanabe F et al. Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women. Clin Cosmet Investig Dermatol. 2014;7:267-274. doi:10.2147/CCID.S68424

NAD+ Decline and Cellular Aging

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme for over 500 enzymatic reactions including mitochondrial ATP production, sirtuin-mediated DNA repair, and PARP-dependent genome maintenance. NAD+ levels decline approximately 50% between ages 40 and 60, directly contributing to mitochondrial dysfunction, increased DNA damage accumulation, and reduced cellular repair capacity. Intravenous NAD+ precursor infusions restore intracellular NAD+ pools, reactivating sirtuin longevity pathways (SIRT1-7) and improving mitochondrial biogenesis. Clinical observations indicate that serial NAD+ anti-aging IV therapy sessions improve subjective energy levels, cognitive clarity, and skin elasticity markers over 4-8 week protocols.

Rajman L et al. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metab. 2018;27(3):529-547. doi:10.1016/j.cmet.2018.02.011

High-Dose Intravenous Vitamin C for Collagen and Antioxidant Protection

Ascorbic acid (vitamin C) serves as the essential cofactor for prolyl hydroxylase and lysyl hydroxylase enzymes required for stable collagen triple-helix formation. Oral vitamin C absorption plateaus at approximately 200mg due to intestinal transporter saturation, yielding plasma concentrations of 70-80 micromol/L. Intravenous vitamin C administration at 10,000-25,000mg achieves transient plasma concentrations of 1,000-9,000 micromol/L — 50 to 70 times higher than oral maxima. At these pharmacological concentrations, anti-aging IV therapy with vitamin C provides potent antioxidant protection through direct ROS scavenging, supports robust collagen synthesis essential for skin firmness, and enhances immune function through neutrophil and lymphocyte stimulation.

Padayatty SJ et al. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med. 2004;140(7):533-537. doi:10.7326/0003-4819-140-7-200404060-00010

The combination of glutathione, NAD+ precursors, and vitamin C in a single anti-aging IV therapy protocol creates synergistic effects: glutathione recycles oxidized vitamin C back to its active form, vitamin C supports glutathione synthesis, and NAD+ ensures adequate cellular energy for all repair processes. This triad approach to intravenous anti-aging at RE:BERRY Myeongdong addresses oxidative damage, energy decline, and structural protein loss simultaneously.

Weschawalit S et al. Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 2017;10:147-153. doi:10.2147/CCID.S128339