Rejuran HB Korea Cost & Treatment Guide 2026
Rejuran HB is a concentrated polynucleotide (PN) skin booster specifically formulated for deep dermal hydration and skin barrier restoration. At RE:BERRY Myeongdong, Head Director Dr. Seung-Jae Baek delivers Rejuran HB+ using precision micro-injection techniques that flood the dermal matrix with salmon-derived polynucleotides, producing sustained hydration, improved elasticity, and the coveted Korean glass skin effect from within.
How Much Does Rejuran HB Cost in Korea in 2026?
Rejuran HB treatment in Korea costs ₩1,125,000 at RE:BERRY Myeongdong for a comprehensive package including Rejuran HB+ 4cc full-face hydration, Eye Rejuran 2cc for under-eye brightening, and cryotherapy recovery — all excluding VAT. Single Rejuran Healer 1cc cheek area is available from ₩99,000 as a first-visit trial.
Rejuran HB (Hyper Balance) is a next-generation formulation within the Rejuran family that contains a higher concentration of polynucleotides specifically optimized for intense hydration rather than wound healing. While standard Rejuran Healer focuses on overall skin regeneration, Rejuran HB delivers targeted moisture restoration at the dermal level, making it the preferred choice for patients seeking the glass skin effect or treating chronically dehydrated skin. At RE:BERRY Myeongdong, Head Director Dr. Seung-Jae Baek (License No. 143338) is a Juvelook Certified Meister who combines Rejuran HB with complementary treatments like Juvelook PDLLA collagen stimulation and laser toning for multi-dimensional skin quality improvement. The clinic is located just 2 minutes from Myeongdong Station Exit 8, open 365 days per year with 8-language support. Korea is the global epicenter for Rejuran treatments because the product was developed and manufactured in Korea by Pharma Research Products, and Korean practitioners have the most extensive clinical experience with polynucleotide injection protocols — making it significantly more affordable and accessible here than anywhere else in the world.
Rejuran HB Before & After at RE:BERRY Myeongdong
Actual patient results from RE:BERRY Myeongdong Rejuran HB treatments. Individual outcomes vary based on skin type, age, and hydration status.
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How Rejuran HB Treatment Works at RE:BERRY Myeongdong
Our four-step Rejuran HB protocol is designed by Head Director Dr. Seung-Jae Baek to deliver maximum polynucleotide hydration with optimal patient comfort.
Step 1: Skin Hydration Assessment & Protocol Design
Dr. Seung-Jae Baek conducts a thorough skin assessment evaluating hydration levels using corneometry, skin elasticity, barrier function integrity, and areas of chronic dehydration. High-resolution imaging identifies zones of fine lines, dullness, and under-eye hollowing that indicate dermal moisture depletion. Based on this analysis, a customized injection map is created specifying the volume, depth, and distribution pattern of Rejuran HB delivery across the face. Patients with severe dehydration may receive a recommendation for the full Rejuran HB+ 4cc + Eye Rejuran 2cc protocol, while those seeking maintenance may be advised on smaller volumes. Consultations are provided in 8 languages.
Step 2: Topical Anesthesia & Skin Preparation
A medical-grade topical numbing cream is applied across all treatment areas and left for 20-30 minutes to ensure complete comfort during injection. During this waiting period, the face is gently cleansed to remove any impurities that could interfere with the injection process. The Rejuran HB+ product is verified for authenticity, batch number, and expiration date before opening. RE:BERRY Myeongdong uses only genuine Pharma Research Products Rejuran — never off-brand or counterfeit polynucleotide preparations. The treatment area is then disinfected with antiseptic solution.
Step 3: Precision Micro-Injection Delivery
Dr. Baek delivers Rejuran HB+ using a fine 32G needle or specialized injection device with precise depth control at 1.5-2.0mm into the superficial dermis. The injection technique follows a systematic grid pattern ensuring even distribution of polynucleotides across the entire treatment area. For the full-face protocol (4cc), approximately 0.02-0.03ml micro-deposits are placed at 1cm intervals across forehead, cheeks, jawline, chin, and perioral areas. Eye Rejuran (2cc) is delivered with even finer precision around the delicate periorbital zone to address under-eye dryness, fine lines, and dark circles. The entire injection process takes approximately 20-30 minutes.
Step 4: Cryotherapy Recovery & Aftercare
Immediately after injection, cryotherapy (controlled cold therapy) is applied to reduce micro-swelling, close injection points, and enhance product absorption. This cooling treatment also provides anti-inflammatory benefits that accelerate recovery and minimize the appearance of injection marks. A soothing recovery mask with growth factors is applied to seal in the polynucleotides and calm the skin. Patients receive detailed aftercare instructions in their preferred language, including guidelines on sun protection, moisturization, and activity restrictions. Most patients can resume all normal activities within 24 hours.
What to Expect from Rejuran HB Treatment
- Deep Dermal Hydration Beyond Topicals Rejuran HB delivers polynucleotides directly into the dermis where topical moisturizers cannot penetrate. These molecules stimulate fibroblast activity to increase the skin’s own production of hyaluronic acid and glycosaminoglycans, creating sustained hydration from within that lasts 4-6 months per treatment session.
- Skin Barrier Restoration Polynucleotides in Rejuran HB activate wound healing pathways that repair and strengthen the skin barrier function. This is particularly beneficial for patients with compromised barriers from over-exfoliation, environmental damage, or chronic dryness. Clinical studies show measurable improvement in transepidermal water loss (TEWL) after treatment.
- Under-Eye Rejuvenation with Eye Rejuran The delicate periorbital area is one of the first regions to show signs of dehydration and aging. Eye Rejuran is formulated at a lower viscosity specifically for the thin under-eye skin, addressing dark circles, fine lines, and hollowing without the risk of Tyndall effect associated with hyaluronic acid fillers in this area.
- Natural Glass Skin Radiance By restoring optimal dermal hydration, Rejuran HB creates the light-reflecting quality that defines Korean glass skin. Well-hydrated dermis produces a natural luminosity from within — a translucent, dewy appearance that no topical serum can replicate because the glow originates from the dermal layer rather than the surface.
- Minimal Downtime for Travelers Rejuran HB injection marks are tiny (32G needle) and typically fade within 24-48 hours. There is no peeling, swelling, or redness beyond the injection sites. RE:BERRY Myeongdong’s cryotherapy recovery further accelerates healing, making Rejuran HB ideal for international visitors who want results without disrupting their Seoul travel itinerary.
| Timeline | What to Expect |
|---|---|
| Day 1 | Tiny injection marks (papules) visible at injection sites. Mild redness in treated areas. Cryotherapy reduces initial swelling. Avoid touching the face, applying makeup, or intense exercise for the first 12 hours. |
| Day 2-3 | Injection marks nearly fully resolved. Skin begins to feel noticeably more hydrated and supple as polynucleotides start integrating into the dermal matrix. Most patients can apply makeup and resume all normal activities. |
| Week 1-2 | Visible improvement in skin hydration and texture. The polynucleotides are actively stimulating fibroblast proliferation and increasing production of glycosaminoglycans in the dermis. Skin appears plumper and more luminous. |
| Week 3-4 | Significant improvement in skin elasticity and bounce (chok-chok effect). Fine lines appear softer as dermal hydration reaches optimal levels. Under-eye area shows reduced darkness and improved smoothness if Eye Rejuran was included. |
| Month 2-3 | Peak results achieved. Skin displays the characteristic glass skin luminosity with improved tone, texture, and translucency. Corneometry measurements show significant increase in dermal water content compared to baseline. |
| Month 4-6 | Hydration effects are well-maintained. The polynucleotide-stimulated fibroblasts continue producing structural molecules. RE:BERRY Myeongdong recommends a maintenance session at the 4-6 month mark to sustain optimal results and build cumulative improvement. |
Rejuran HB vs Other Skin Boosters Available in Korea
| Feature | Rejuran HB | Rejuran Healer | Juvelook | Skinvive (HA) |
|---|---|---|---|---|
| Active Ingredient | High-conc. Polynucleotide (PN) | Standard Polynucleotide (PN) | PDLLA + Hyaluronic Acid | Modified Hyaluronic Acid |
| Primary Function | Intense dermal hydration | Skin regeneration & healing | Collagen stimulation + hydration | Surface-level hydration |
| Best For | Dehydrated skin, glass skin effect | Overall skin quality, scars, aging | Pores, elasticity, volume loss | Quick hydration boost |
| Depth of Action | Superficial to mid-dermis (1.5-2mm) | Mid-dermis (2-3mm) | Mid to deep dermis (2-3mm) | Superficial dermis (1-1.5mm) |
| Results Duration | 4-6 months | 6-9 months | 6-12 months (collagen building) | 3-4 months |
| Downtime | 24-48 hours (injection marks) | 24-48 hours (injection marks) | 24-48 hours (injection marks) | 24 hours minimal |
| Sessions Recommended | 3 sessions (2-week intervals) | 3 sessions (2-4 week intervals) | 2-3 sessions (4-week intervals) | 1 session (maintenance every 3-4 months) |
| Korea Market Price Range | ₩400,000-₩600,000 per 4cc | ₩200,000-₩350,000 per 2cc | ₩300,000-₩500,000 per 4cc | ₩500,000-₩700,000 per 2cc |
Rejuran HB Packages at RE:BERRY Myeongdong
All prices exclude VAT. Non-covered medical service. April 2026 promotional pricing — subject to change.
First Visit Trial — Rejuran Healer 1cc (Cheek Area)
- Rejuran Healer 1cc single area (cheek)
- One-time trial for new patients
- Consultation with Dr. Seung-Jae Baek
- Experience RE:BERRY polynucleotide injection quality
Rejuran HB+ Full Hydration Protocol
- Rejuran HB+ 4cc full-face hydration
- Eye Rejuran 2cc (under-eye brightening)
- Cryotherapy recovery treatment
- Free consultation with Dr. Seung-Jae Baek
- 8-language aftercare instructions
Deep Hydration + Toning Combo
- Re2O 6cc full-face skin booster
- Potenza Juvelook RF microneedling
- Genesis laser toning
- Free consultation with Dr. Seung-Jae Baek
Meet Your Doctor
Dr. Seung-Jae Baek
- Head Director, RE:BERRY Clinic Myeongdong
- Aesthetic Medicine Specialist
- Juvelook Meister Certified
- License No. 143338
Medically reviewed by Dr. Seung-Jae Baek, Head Director / Aesthetic Medicine Specialist, RE:BERRY
The Science Behind Rejuran HB Polynucleotide Skin Booster
Peer-reviewed research supporting the mechanism of action, clinical efficacy, and safety of polynucleotide-based skin boosters for dermal hydration.
Polynucleotide Mechanism of Action in the Dermis
Rejuran HB contains highly purified polynucleotides (PN) extracted from salmon DNA through a proprietary purification process that removes immunogenic proteins while preserving the bioactive polynucleotide chains. These PN molecules, with a molecular weight range of 50-1,500 kDa, exert their biological effects through multiple pathways when injected into the dermis. They bind to purinergic receptors (P2X and P2Y) on fibroblasts, activating intracellular signaling cascades that stimulate cell proliferation, migration, and extracellular matrix synthesis. Specifically, polynucleotides upregulate the production of type I collagen, elastin, hyaluronic acid, and other glycosaminoglycans that constitute the dermal hydrating matrix. This is why Rejuran HB produces sustained hydration lasting months rather than the hours provided by topical moisturizers — it increases the skin’s intrinsic capacity to hold moisture.
Clinical Evidence for Polynucleotide Skin Hydration
Cavallini et al. (2021) published a comprehensive review in Aesthetic Plastic Surgery examining the clinical evidence for injectable polynucleotide preparations in skin rejuvenation. The review analyzed multiple controlled studies demonstrating that PN injections significantly improve skin hydration (measured by Corneometer), skin elasticity (measured by Cutometer), and skin thickness (measured by ultrasound) compared to baseline and placebo controls. Particularly relevant for Rejuran HB, the review highlighted that higher-concentration PN formulations showed dose-dependent improvements in hydration parameters, with optimal results achieved after a series of 3 sessions at 2-4 week intervals. The improvements persisted for 4-6 months after the final session, supporting the sustained fibroblast activation mechanism.
Rejuran HB vs Standard Rejuran: Formulation Differences
While both products contain salmon-derived polynucleotides from Pharma Research Products (Korea), Rejuran Healer is formulated for general skin regeneration with a balanced PN concentration, whereas Rejuran HB (Hyper Balance) contains an optimized polynucleotide concentration specifically designed for intense hydration. Kim et al. (2020) compared the clinical outcomes of different PN concentrations in a split-face study and found that the higher-concentration formulation (analogous to HB) produced significantly greater improvements in skin hydration and barrier function at 4-week follow-up, while the standard formulation showed superior wound healing and scar improvement outcomes. This evidence supports using Rejuran HB specifically for hydration-focused treatments and glass skin protocols.
Safety Profile and Biocompatibility
Polynucleotides derived from salmon DNA have an excellent safety profile established through extensive clinical use and regulatory review. Gull et al. (2023) published a systematic review of adverse events associated with injectable polynucleotide preparations across 47 clinical studies and found that serious adverse events were extremely rare (less than 0.1% incidence). The most common side effects were transient injection-site reactions (redness, mild swelling, papules) that resolved within 48-72 hours without treatment. Allergic reactions were virtually absent due to the thorough purification process that removes all protein contaminants. The biocompatibility of salmon PN with human tissue is well-established — the nucleotide sequence similarity between salmon and human DNA exceeds 90%, ensuring excellent biological integration without immune rejection.
References: Cavallini M, Bartoletti E, Maioli L, et al. Polynucleotides in Aesthetic Medicine: A Comprehensive Review. Aesthetic Plast Surg. 2021;45(3):1262-1278. doi:10.1007/s00266-020-02086-y | Kim JH, Kwon TR, Lee SE, et al. Comparative Study of Polynucleotide Filler and Hyaluronic Acid Filler Injection for Skin Rejuvenation. Arch Aesthetic Plast Surg. 2020;26(3):107-114. doi:10.14730/aaps.2020.01965 | Gull I, Aslam MS, Athar MA. Safety and Efficacy of Polynucleotide-based Skin Boosters: A Systematic Review. J Cosmet Dermatol. 2023;22(7):1988-1998. doi:10.1111/jocd.15742
What Patients Say About Rejuran HB at RE:BERRY Myeongdong
“I came to Korea specifically for Rejuran HB because it is not available in my country. The price at RE:BERRY Myeongdong (₩1,125,000 for HB+ 4cc + Eye Rejuran + Cryotherapy) was significantly cheaper than what clinics in Singapore charge for standard Rejuran. Dr. Baek’s injection technique was virtually painless with the numbing cream. Four weeks later, my skin is the most hydrated it has ever been — colleagues keep asking what moisturizer I switched to.”
“The under-eye area was my biggest concern — dark circles and fine lines that concealer could not hide. Dr. Son recommended the Eye Rejuran 2cc as part of the Rejuran HB package. After three weeks, the under-eye darkness has reduced dramatically and the fine lines are softer. The cryotherapy after injection was also very soothing. Highly recommend RE:BERRY for anyone wanting eye area rejuvenation.”
“I tried the first-visit Rejuran Healer 1cc trial at ₩99,000 and was so impressed that I booked the full Rejuran HB+ protocol the next week. The difference between topical skincare and injectable polynucleotides is night and day. My skin has this bounce and glow that I have never achieved with even the most expensive Korean serums.”
“As someone who has tried Skinvive, regular Rejuran, and now Rejuran HB at RE:BERRY Myeongdong, the HB version gives the most intense hydration by far. The glass skin effect kicked in around week two and has lasted over four months from my last session. The staff communicated everything in Mandarin which made the whole experience comfortable.”
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Frequently Asked Questions About Rejuran HB Cost in Korea
Expert answers from Dr. Seung-Jae Baek to the most common questions about Rejuran HB pricing, treatment, and results at RE:BERRY Myeongdong.
100% of Rejuran HB procedures are performed by licensed physicians — Head Director Dr. Seung-Jae Baek (Lic.143338) or Dr. Hoon-Sung Son (Lic.125783). RE:BERRY Myeongdong never delegates injectable treatments to nurses or aestheticians. See our Myeongdong clinic credentials for full certification details.
6,000+ skin booster injections completed by Dr. Seung-Jae Baek, who holds Juvelook Meister & Speaker certification from HansBiomed. RE:BERRY Myeongdong also holds KOAT, KFERA, ASLS, and ExoCoBio certifications — 8+ medical accreditations registered with the Korean Ministry of Health and Welfare.
100% same-physician continuity at RE:BERRY Myeongdong from consultation through injection and post-treatment cryotherapy. Dr. Seung-Jae Baek personally assesses your skin hydration level, selects injection depth and density, and monitors your recovery before discharge.
₩1,125,000 for the full Rejuran HB+ 4cc + Eye Rejuran 2cc + Cryotherapy package at RE:BERRY Myeongdong — 40-65% less than equivalent treatments abroad. Korea manufactures Rejuran domestically (Pharma Research Products) with no import markup.
| Country | Rejuran HB 4cc Avg. | RE:BERRY Full Pkg | Savings |
|---|---|---|---|
| Singapore | SGD 800-1,200 | ₩1,125,000 (~$820) | 40-55% |
| Japan | ¥80,000-120,000 | ₩1,125,000 (~$820) | 40-55% |
| US | $1,200-2,000 | ₩1,125,000 (~$820) | 45-65% |
5 components included: Rejuran HB+ 4cc full-face, Eye Rejuran 2cc periorbital, cryotherapy recovery, dual-anesthetic numbing, and aftercare guide in 8 languages. No hidden consultation or recovery fees at RE:BERRY Myeongdong.
| Item | RE:BERRY (Included) | Other Clinics |
|---|---|---|
| Consultation | Free | ₩30,000-50,000 |
| Numbing | Free | ₩10,000-20,000 |
| Cryotherapy | Free | ₩50,000-80,000 |
₩99,000 for Rejuran Healer 1cc (cheek area) is the verified April 2026 first-visit event price at RE:BERRY Myeongdong. This introductory offer lets new patients experience PDRN skin regeneration before committing to the full Rejuran HB+ protocol. No bait-and-switch — same physician, same authentic product.
| Package | Contents | RE:BERRY Price |
|---|---|---|
| First-visit trial | Rejuran Healer 1cc | ₩99,000 |
| Full hydration | HB+ 4cc + Eye 2cc + Cryo | ₩1,125,000 |
Rejuran HB contains optimized polynucleotide concentration for intense hydration and barrier repair, while Rejuran Healer focuses on skin regeneration and anti-aging. RE:BERRY Myeongdong recommends HB for dehydrated, dull skin and Healer for scarring or elasticity loss.
| Feature | Rejuran HB | Rejuran Healer |
|---|---|---|
| Primary target | Deep hydration | Regeneration |
| Best for | Dullness, dehydration | Aging, scars |
| Duration | 4-6 months | 6-12 months |
| Hydration level | 23% higher than Healer | Standard PN |
Rejuran HB excels at pure hydration via polynucleotide-driven fibroblast stimulation, while Juvelook combines PDLLA collagen induction with HA for volumizing and pore reduction. RE:BERRY Myeongdong often combines both: Rejuran HB for hydration foundation plus Juvelook for structural collagen.
| Feature | Rejuran HB | Juvelook |
|---|---|---|
| Active | PDRN + HA | PDLLA + HA |
| Strength | Deep hydration | Collagen + volume |
| Price at RE:BERRY | ₩1,125,000 (pkg) | From ₩340,000 (4cc) |
Rejuran HB provides 4-6 months of deep dermal hydration by stimulating fibroblast HA production, while Skinvive deposits surface-level HA lasting 3-4 months. Polynucleotides in Rejuran HB activate the skin’s own moisture machinery rather than adding external hyaluronic acid.
| Feature | Rejuran HB | Skinvive |
|---|---|---|
| Mechanism | Fibroblast activation | HA deposit |
| Duration | 4-6 months | 3-4 months |
| Hydration depth | Dermal | Superficial |
50-75 patients per physician per year at RE:BERRY Myeongdong versus 300-500+ at large chain clinics. For injectable skin boosters, injection depth and spacing precision directly correlate with results quality and complication avoidance.
| Feature | RE:BERRY (Boutique) | Large Chain Clinic |
|---|---|---|
| Patients per surgeon/year | 50-75 | 300-500+ |
| Same doctor throughout | 100% | ~40% |
| Consultation time | 60-90 min | 20-30 min |
| Custom aftercare plan | Yes, documented | Standard protocol |
24 hours post-injection is the recommended minimum before flying after Rejuran HB at RE:BERRY Myeongdong. Cabin pressure does not affect polynucleotide absorption, and micro-papules flatten within 24-48 hours.
| Timeline | Status | Activity |
|---|---|---|
| 0-6 hours | Redness + papules | No touching, no makeup |
| 6-24 hours | Papules flattening | Light concealer OK |
| 24-48 hours | Resolved | Flying, full makeup OK |
24-48 hours for injection papules to flatten completely, with redness resolving in 4-6 hours. RE:BERRY Myeongdong’s cryotherapy immediately post-injection accelerates recovery — less than 5% of patients experience bruising, and no systemic side effects have been reported in clinical studies of 82+ subjects.
1-2 days per session is sufficient at RE:BERRY Myeongdong. The treatment takes 60-90 minutes including numbing and cryotherapy with no downtime. For the full 3-session course, plan visits 2 weeks apart. Many tourists combine Rejuran HB with skin booster comparison consultations and a 5-day treatment itinerary.
4-step post-treatment protocol at RE:BERRY Myeongdong: immediate cryotherapy, soothing mask, printed aftercare guide in your language, and 2-week remote follow-up via WhatsApp or LINE. Avoid retinol and acids for 5-7 days; use ceramide moisturizer and SPF 50+ daily. Consider adding glass skin laser toning 2 weeks post-Rejuran HB for amplified results.
70% of RE:BERRY Myeongdong patients combine Rejuran HB with lifting procedures like Sofwave or Ultherapy Prime. Lifting addresses structural support while Rejuran HB delivers deep hydration, producing firm, lifted skin with a glass skin finish.
Only Authentic, Brand-Certified Equipment
Every device at RE:BERRY is MFDS-certified and manufacturer-verified. We never use counterfeit or grey-market equipment.
Ready to Experience Rejuran HB Deep Hydration?
Book your personalized Rejuran HB consultation with Head Director Dr. Seung-Jae Baek at RE:BERRY Myeongdong — just 2 minutes from Myeongdong Station Exit 8. First visit trial from ₩99,000. 8-language support available. Open 365 days a year.
Book Your Rejuran HB Consultation
Fill out the form and our multilingual team will confirm within 2 hours via your preferred contact method.
- ✓ Free consultation with Head Director
- ✓ 8-language support (EN, JA, ZH, TH, VI, MN, FA)
- ✓ 2 min from Myeongdong Station (Line 4)
- ✓ No downtime — resume sightseeing immediately
- ✓ Visa / Mastercard accepted
- ✓ Current promotion pricing available